Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling

Polo-like kinase 1 (PLK1) is a key cell cycle regulator implicated in the development of various cancers, including prostate cancer.However, the functions of PLK1 beyond cell cycle regulation remain poorly characterized.Here, we report that PLK1 overexpression in prostate epithelial cells triggers oncogenic transformation.It also results in google

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Using Search Trends to Analyze Web-Based Interest in Lower Urinary Tract Symptoms-Related Inquiries, Diagnoses, and Treatments in Mainland China: Infodemiology Study of Baidu Index Data

BackgroundLower urinary tract symptoms (LUTS) are one of the most commonly described urination disorders worldwide.Previous investigations have focused predominantly on the prospective identification of cases that meet the researchers’ criteria; thus, the genuine demands regarding LUTS from patients and related issues may be neglected.ObjectiveWe

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Laboratory Supported Lectures on Modeling: Transformer Case

The modeling process of a component or system consists of several steps, which are rarely entirely covered in undergraduate courses.Moreover, theoretical and laboratory lectures focus on different stages on modeling, and are commonly taught at different periods, which may negatively affect the learning process.Thus, this paper proposes a set of lec

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